S1486 AEE788 (Synonyms AEE-788, NVP-AEE 788)

标准品  现货  纯度 >99%


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血管新生Angiogenesis / Tyrosine-Kinase


促使血管新生的物质很多。目前被研究最多的是vascular endothelial growth factor (VEGF)及basic fibroblast growth factor (bFGF)。这两种物质的量在许多癌症患者的血液及尿液中有增加的现象。而抑制血管新生的物质也很多,根据其作用可分为四大类:  

 

1) 可抑制肿瘤分泌促使血管新生物质的物质。如干扰素(interferon)可抑制癌细胞分泌bFGF。 

2) 可抑制促使血管新生物质作用的物质。如suramin可抑制bFGF与其受体的结合。  

3) 可抑制内皮细胞对促使血管新生物质的反应的物质。如thrombospondin及angiostatin。

4) 可干扰周边结缔组织间质(matrix)的代谢的物质。

 

血管新生Angiogenesis

Angiogenesis/Receptor Tyrosine Kinases Pathway



Angiogenesis is the process of the growth of new blood vessels from pre-existing vessels. Angiogenesis can be induced by solid tumor growth. In the meantime, angiogenesis provides solid tumor with oxygen and nutrients to make it reach a certain size.

Receptor tyrosine kinases (RTK)s are the high-affinity cell surface receptors that transmit extracellular signals into the cell. Many RTK classes have been identified, such as EGFR family, FGFR family, VEGFR family, RET receptor family and Eph receptor Family. Overexpression or functional mutations of receptor tyrosine kinases lead to uncontrolled cell growth and cancer. 


 



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Selleck癌症肿瘤研究周刊


Stu.la 司途拉生物
Stu.la 司途拉生物