Selleck ABT-737 指导血液肿瘤治疗的检测

selleck-abt-737
selleck-abt-737

Test May Help Guide Blood Cancer Treatment
指导血液肿瘤治疗的检测

Scientists h*e developd a new test to spot a blood cancer that is vulnerable to a promising type of experimental drug that promotes cancer cell death. 

科学家们开发了一种用于发现特殊血液肿瘤的新试验,该种血液肿瘤对一种有望成为促进癌细胞凋亡的实验*物易感。

The test was developed by scientists at the Dana Farber Cancer Institute in Boston. Using the test, they found that chronic lymphocytic leukemia (CLL) is an "easy mark" for the experimental drug ABT-737.
波士顿Dana Farber癌症中心的科学家们开发了这种试验。他们发现通过这种试验,试验*物ABT-737易于标记慢性淋巴细胞性白血病。

The findings are published in the January issue of the Journal of Clinical Investigation.
这些发现发表于《临床研究》杂志一月刊。

CLL cells are strongly dependent on a survival molecule called Bcl-2, which switches off self-destruct signals in the cancer cells. ABT-737 neutralizes Bcl-2, which leads to the release of molecules that trigger suicide in the cancer cells, the study said.
慢性淋巴细胞性白血病的细胞依赖生存分子Bcl-2,该分子可以关闭了癌症细胞的凋亡信号。研究表明,实验药物ABT-737可定位Bcl-2分子,释放多种分钟启动肿瘤细胞*程序。

Each year, about 10,000 people in the United States are diagnosed with CLL, which is currently incurable.
美国每年约有10,000人被诊断为慢性淋巴细胞性白血病,慢淋目前是不可治愈的。

It's expected that ABT-737 and similar drugs that prompt cancer cells to die will be relatively non-* to most healthy cells, because healthy cells don't rely so he*ily on Bcl-2 to stay alive.
促进癌细胞死亡的ABT-737和其同类药物对大多数健康细胞是相对无害的,因为健康细胞无需过多依赖Bcl-2生存。

"It's essential to figure out which cancers are going to respond to the drug by identifying the cells that are dependent on Bcl-2 for survival. Up to now, there hasn't been a way to do this,"Dr. Anthony Letai, an assistant professor of medicine at Harvard Medical School, said in a prepared statement. The research on the test was conducted in his laboratory. The researchers are now working on making the test more automatic.
哈佛医学院助理教授安东尼博士在一场报告中说:“通过鉴别是否依赖Bcl-2来判断肿瘤细胞是否对该药物应答的方法是卓有成效的。到目前为止,还没有没有一种方法可以做到这一点。”本试验是在他的实验室中进行的。研究人员正致力于使该试验更易于自动化操作。

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Comments: 1
  • #1

    痛并快乐着 (Sunday, 31 July 2011 03:34)

    ABT-737的用处还不小呀,能治白血病?现在Selleck的ABT-737好像降价了,以前好贵。现在只有以前价格的三分之一。美国赛力克的737关键是发了好多文章还有图,让人用着放心。



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