美国赛力克化学Src-bcr-Abl靶点有哪些分子?

Cat.No. Product Name Feedback 订购电话

S1134

AT9283

021-33766115
AT9283 is a small molecule a multi-targeted c-ABL, JAK2, Aurora A and B inhibitor with of 4, 1.2, 1.1 and approximate 3 nM for Bcr-Abl(T3151), Jak2 and Jak3, aurora A and B, respectively.
 
S1369

Bafetinib(INNO-406)

021-33766115
Bafetinib (INNO-406) is an orally available, dual Abl/Lyn kinase inhibitor (cell IC50 : 11 ~ 22 nM).
 
S1014

Bosutinib (SKI-606)

021-33766115
Src family kinase inhibitor. inhibited migration of breast cancer cell lines with IC50 values of 0.1 to 0.3 umol/L.
 
S1107

Danusertib (PHA-739358)

021-33766115
Danusertib (PHA-739358) is a pyrrolo-pyrazole and small molecule Aurora kinases and Bcr-Abl kinase inhibitor with IC50 of 13, 79, and 61 nM for Aurora A, B, and C, respectively.
 
S1021

Dasatinib (BMS-354825)

021-33766115
Dasatinib also known as BMS-354825, Sprycel, BMS354825 is ATP-competitive, dual SRC/ABL inhibitor. BMS-354825 inhibits all members of the Src family, including c-Src, Lck, Fyn, and Yes (IC50 < 1.1nmol/L).
 
S2634

DCC-2036 

  021-33766115
DCC-2036 is an ABL switch control inhibitor with IC50 of 0.8 and 2 nM for u-ABL1native and p-ABL1native, respectively.
 
S5002

FTY720(Fingolimod)

  021-33766115
FTY720 Fingolimod Gilenia is Src-bcr-Abl Inhibitor & S1P receptor agonist with IC50 of 0.137, 10.98 nM for (S)- and (R)- FTY720-phosphate.
 
S1033

Nilotinib (AMN-107)

  021-33766115
Inhibitor of BCR-ABL, IC50 < 30nM
 
S2202

NVP-BHG712

  021-33766115
NVP-BHG712 is a small molecule specific EphB4, VEGFR2, c-raf, c-src and c-Abl kinase inhibitor with ED50 of 25 nM, 4.2, 0.4, 1.3 and 1.7μM, respectively.
 
S1490

Ponatinib (AP24534)

  021-33766115
Ponatinib (AP24534) is a novel potent, orally available small molecule multitargeted kinase inhibitor with IC50 of 0.37, 2, 1.5, 2.2, 1.1, 1and 0.24 nM for native pan-BCR-ABL, mutated form, VEGFR2, FGFR1, PDGFRα, mutant FLT3 phosphorylation and LYN.
 
S2622

PP-121 

  021-33766115
PP121 is a multitargeted dual receptor tyrosine kinases inhibitor with IC50 of 0.052, 1.4, 0.15, 1.1, 0.06, 0.01and 0.002 μM for p110α, p110β, p110δ, p110γ, DNA-PK, mTOR and PDGFR, respectively.
 
S2391

Quercetin(Sophoretin)

  021-33766115
Quercetin is a PI3K and PKC inhibitor with IC50 of 3.8 μM and 15µg/ml.
 
S1006

Saracatinib (AZD0530)

021-33766115
Saracatinib (AZD0530) is a highly selective, orally available, dual-specific Src/Abl kinase inhibitor with IC50 of 2.7 and 30 nM for c-Src and Abl kinase, respectively.
 
S2243

WP1130

  021-33766115
WP1130 is a novel selective small molecular deubiquitinase inhibitor and a Bcr/Abl destruction pathway activator with an IC50 of 1.8 μM for K562 cells.

 

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