现货,AR-42 (HDAC-42),CAS号:935881-37-1,美国进口,HDAC-HSP-Aurora , HDAC ,HDAC 抑制剂,sellek,S2244

信号转导通路:  HDAC-HSP-Aurora >> HDAC >> HDAC 抑制剂 >> 

信号转导通路: HDAC-HSP-Aurora >> HDAC >> HDAC 抑制剂 >> AR-42 (HDAC-42)http://www.selleck.cn/ar-42-hdac-42-S2244.html

技术数据:

分子量(MW): 312.36

化学式:

C18H20N2O3

 

溶解度: DMSO ≥63mg/mL Water <1mg/mL Ethanol ≥63mg/mL

纯度: >99%

稳定性: at -20℃ 2 years

CAS号: 935881-37-1

生物活性

 

 

AR-42 is a novel HDAC inhibitor with an IC50 of 0.61 μM for acute lymphoblastic leukemia (697) cell lines.

In chronic lymphocytic leukemia (CLL) cells, the 48-hr LC50 of AR-42 is 0.76 μM. AR-42 produces dose- and time-dependent acetylation both of histones and tubulin, and induces caspase-dependent apoptosis that is not reduced in the presence of stromal cells. AR-42 significantly reduced leukocyte counts and/or prolonged survival in three separate mouse models of B-cell malignancy without evidence of toxicity. AR-42 has in vitro and in vivo efficacy at tolerable doses. In additon, AR-42 promoted hyperacetylation of H3, H4, and alpha-tubulin, and up-regulation of p21. Down-regulation of Kit occurred after AR-42 treatment via inhibition of Kit transcription. [1][2]

 

 

 

参考文献

The novel deacetylase inhibitor AR-42 demonstrates pre-clinical activity in B-cell malignancies in vitro and in vivo. Lucas DM et al. PLoS One. 2010 Jun 3;5(6):e10941.

AR-42, a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit. Lin TY et al. Blood. 2010 May 27;115(21):4217-25.

 

退换货政策

1、 退换货只针对已付款用户。一张订单Selleck只提供一次退换货服务,为了确保您的权益,请考虑周全后与我们联系。

2、请您确保退换货时,商品、配件、赠品及各种包装完整。

3、因您个人原因造成的商品损坏(如自行使用、分装、受潮、变质、非原物品的等)将不予退换。

4、Selleck目前只支持商品一换一服务,换货时无法加定商品。

5、如您购买商品时Selleck上海办事处已向您提供发票,则办理退货或订单金额发生变更的换货时,请将发票随商品一同返还给Selleck上海办事处赛导通生物科技(上海)有限公司,请您妥善保管发票,如发票丢失,将无法办理退换货。

6、您的订单若办理退换货,运费金额会在您的实际退款中扣除。

 

Write a comment

Comments: 0



赛导通生物科技联系方式:


上海市黄浦区江西中路261号509室,

近南京东路外滩


电话 400-168-1698


传真 021 3326 0586


邮箱: info@selleck.cn 

 技术: tech@selleck.cn



Selleck癌症肿瘤研究周刊


Stu.la 司途拉生物
Stu.la 司途拉生物