现货,Bosutinib (SKI-606) ,CAS号:380843-75-4,美国进口, 受体酪氨酸激酶(RTK) ,SRC ,SRC 抑制剂和化合物,selleck,S1014

信号转导通路: 受体酪氨酸激酶(RTK) >> SRC >> SRC 抑制剂和化合物 >> Bosutinib (SKI-606)http://www.dxy.cn/redirect?url=http://selleck.cn/bosutinib-S1014.html

技术数据:

分子量(MW): 530.45

化学式:

C26H29Cl2N5O3

 

溶解度: DMSO ≥53mg/mL Water <1mg/mL Ethanol ≥24mg/mL

纯度: 99%

稳定性: at -20℃ 2 years

CAS号: 380843-75-4

生物活性

 

 

The cellular Src (c-Src) protein is a nonreceptor tyrosine kinase normally maintained in an inactive conformation via intramolecular interactions.[1] c-Src coordinates multiple signaling pathways known to be involved in tumor progression, such as proliferation, survival, motility, angiogenesis, cell-cell communication, adhesion, and invasion.[2,3] SKI-606 inhibited migration of breast cancer cell lines with IC50 values of 0.1 to 0.3 umol/L; After a 48 h treatment with 1 Amol/L SKI-606, all the invasioncompetent cell lines were unable to cross the porous membrane; cell proliferation and survival were unaffected by SKI-606 at concentrations sufficient to block cell migration and invasion.

 

 

 

参考文献

Src in cancer: deregulation and consequences for cell behaviour Margaret C. Frame Biochimica et Biophysica Acta 2002;1602:114– 130

CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES Sheila M. Thomas,Joan S. Brugge Annu. Rev. Cell Dev. Biol. 1997;13:513–609

Newest findings on the oldest oncogene; how activated src does it Margaret C. Frame Journal of Cell Science 2004;117:989-998

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