现货,CUDC-101,CAS号:1012054-59-9,美国进口,HDAC-HSP-Aurora, HDAC , HDAC 抑制剂,selleck,S1194

信号转导通路: HDAC-HSP-Aurora >> HDAC >> HDAC 抑制剂 >> CUDC-101http://www.selleck.cn/cudc-101-S1194.html

技术数据:

分子量(MW): 434.49

化学式:

C24H26N4O4

 

溶解度: DMSO ≥43mg/mL Water <1mg/mL Ethanol <1mg/mL

纯度: >99%

稳定性: -20℃ 2 years

CAS号: 1012054-59-9

生物活性

 

 

CUDC-101 is a potent multitargeted HDAC, EGFR and HER2 inhibitor with IC50 of 4.4, 2.4, and 15.7 nM, respectively. CUDC-101 has novel structure incorporating HDAC inhibitory functionality into the pharmacophore of the EGFR and HER2 inhibitors. In most tumor cell lines tested, CUDC-101 exhibits efficient antiproliferative activity with greater potency than vorinostat (SAHA), erlotinib, lapatinib, and combinations of vorinostat/erlotinib and vorinostat/lapatinib. In vivo, CUDC-101 promotes tumor regression or inhibition in various cancer xenograft models including nonsmall cell lung cancer (NSCLC), liver, breast, head and neck, colon, and pancreatic cancers. [1][2]

 

 

 

参考文献

Discovery of 7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDC-101) as a Potent Multi-Acting HDAC, EGFR, and HER2 Inhibitor for the Treatment of Cancer Hai-Xiao Zhai, Jing Wang,et al. J. Med. Chem. 2010;3, 2000–2009

CUDC-101, a Multitargeted Inhibitor of Histone Deacetylase,Epidermal Growth Factor Receptor, and Human Epidermal Growth Factor Receptor 2, Exerts Potent Anticancer Activity Rudi Bao, Xu Tao, et al. Cancer Res 2010;70:3647-3656

客户反馈数据

退换货政策

1、 退换货只针对已付款用户。一张订单Selleck只提供一次退换货服务,为了确保您的权益,请考虑周全后与我们联系。

2、请您确保退换货时,商品、配件、赠品及各种包装完整。

3、因您个人原因造成的商品损坏(如自行使用、分装、受潮、变质、非原物品的等)将不予退换。

4、Selleck目前只支持商品一换一服务,换货时无法加定商品。

5、如您购买商品时Selleck上海办事处已向您提供发票,则办理退货或订单金额发生变更的换货时,请将发票随商品一同返还给Selleck上海办事处赛导通生物科技(上海)有限公司,请您妥善保管发票,如发票丢失,将无法办理退换货。

6、您的订单若办理退换货,运费金额会在您的实际退款中扣除。

 

Write a comment

Comments: 0



赛导通生物科技联系方式:


上海市黄浦区江西中路261号509室,

近南京东路外滩


电话 400-168-1698


传真 021 3326 0586


邮箱: info@selleck.cn 

 技术: tech@selleck.cn



Selleck癌症肿瘤研究周刊


Stu.la 司途拉生物
Stu.la 司途拉生物