现货,E7080 ,CAS号:417716-92-8,美国进口, 受体酪氨酸激酶(RTK) , VEGFR , VEGFR 抑制剂和化合物,selleck,S1164

信号转导通路: 受体酪氨酸激酶(RTK) >> VEGFR >> VEGFR 抑制剂和化合物 >> E7080http://selleck.cn/e7080-S1164.html

技术数据:

分子量(MW): 426.85

化学式:

C21H19ClN4O4

 

溶解度: DMSO ≥16mg/mL Water <1mg/mL Ethanol ≥1mg/mL

纯度: >99%

稳定性: at -20℃ 2 years

CAS号: 417716-92-8

生物活性

 

 

E7080 is the most potent dual inhibitor of VEGF-R3 tyrosine kinase (IC50=5.2 nM) as well as VEGF-R2 tyrosine kinase (IC50=4.0 nM) among those small-molecule inhibitors of VEGF-R kinases, such as sunitinib, sorafenib, and CEP-7055. It has been evaluated in vitro (pre-clinical) for anti-cancer effects. E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of angiogenesis and lymphangiogenesis. [2,3]

It has had promising results from a phase I clinical trial in 2006 and is being tested in several Phase I and II trials as of October 2009, for example against hepatocellular carcinoma and non-small cell lung carcinoma. [1]

 

 

 

参考文献

Tyrosine Kinase Inhibitor, Suppresses the − E7080, a Multi Progression of Malignant Pleural Mesothelioma with Different Proangiogenic Cytokine Production Profiles Seiji Yano, Van The Trung, et al. Clin Cancer Res 2009;15:7229-7237

Multi-Kinase Inhibitor E7080 Suppresses Lymph Node and Lung Metastases of Human Mammary Breast Tumor MDA-MB-231 via Inhibition of Vascular Endothelial Growth Factor-Receptor (VEGF-R) 2 and VEGF-R3 Kinase Yasuhiro Funahashi, Toshimitsu Uenaka, et al. Clin Cancer Res 2008;14:5459-5465

E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition Junji Matsui,Yuji Yamamoto,et al. Int. J. Cancer 2008;122:664–671

客户反馈数据

如果需要长期保存,请于零下二十度低温保存。

禁止用于人体及治疗!

特定的存储和包装每个产品的信息在产品说明书上都有注明 。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20 ° C ,抗体及蛋白等产品建议-60℃。抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。

 

 

 

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