现货,Elvitegravir (GS-9137) ,CAS号:697761-98-1,美国进口, 微生物学(Microbiology) , Integrase , Integrase 抑制剂,selleck,S2001

信号转导通路: 微生物学(Microbiology) >> Integrase >> Integrase 抑制剂 >> Elvitegravir (GS-9137)http://selleck.cn/elvitegravir-S2001.html

技术数据:

分子量(MW): 447.88

化学式:

C23H23ClFNO5

 

溶解度: DMSO ≥90mg/mL Water <1mg/mL Ethanol ≥90mg/mL

纯度: >99%

稳定性: at -20℃ 2 years

CAS号: 697761-98-1

生物活性

 

 

Elvitegravir (GS-9137) is a human immunodeficiency virus integrase inhibitor with EC50 of 0.7, 2.8 and 1.4 for HIV-1 IIIB, HIV-2 EHO and HIV-2 ROD. Elvitegravir (GS-9137) plays an essential role in the integration of proviral DNA into the host genome. Interestingly, elvitegravir (GS-9137) also showed antiviral activity against murine leukemia virus (MLV) and simian immunodeficiency virus (SIV). EVG inhibited the integration of the HIV-based vector used as a positive control for the luciferase assay (EC50 values of 0.8 nM), as observed in the MAGI assay with HIV-1IIIB. Elvitegravir (GS-9137) suppressed the replication of MLV infection (EC50 values of 5.8 nM) as well as that of the primate retrovirus SIV (0.5 nM), indicating that IN inhibitors have antiviral activity against a broad range of retroviruses. [1][2][3]

 

 

 

参考文献

Molecular mechanisms in retrovirus DNA integration Ernest Asante-Appiah, Anna Marie Skalka Antiviral Research 1997;36 :139–156

A quantitative assay for HIV DNA integration in vivo SCOTT L. BUTLER, MARK S.T. HANSEN,et al. NATURE MEDICINE MAY 2001;7:631-634

Broad Antiretroviral Activity and Resistance Profile of the Novel Human Immunodeficiency Virus Integrase Inhibitor Elvitegravir (JTK-303/GS-9137) Kazuya Shimura,Eiichi Kodama,et al. JOURNAL OF VIROLOGY Jan. 2008;82:764–774

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