现货,Flavopiridol (Alvocidib) ,美国进口,黄酮类化合物,细胞周期(Cell Cycle / Checkpoint) ,CDK 抑制剂 ,目录号 S1230

信号转导通路: 细胞周期(Cell Cycle / Checkpoint) >> CDK >> CDK 抑制剂 >> Flavopiridol (Alvocidib)

技术数据:

分子量(MW): 401.84

化学式:

C21H20ClNO5

 

溶解度: DMSO ≥15mg/mL Water <1mg/mL Ethanol ≥8mg/mL

纯度: >99%

稳定性: -20℃ 2 years

CAS号: 146426-40-6

生物活性

 

 

Nanomolar concentrations of flavopiridol inhibited rhabdoid cell growth (IC50-200nmol/L) , induced G1and G2 arrest, and apoptosis in vitro in a concentration-dependent manner. These effects were correlated with the down-modulation of cyclin D1, up-regulation of p21, and induction of caspase 3/7 activities. Flavopiridol (at 7.5 mg/kg) significantly inhibited the growth of xenografted rhabdoid tumors, and its effect was correlated with the induction of p21 and down-modulation of cyclin D1. [1]

Exposure of HNSCC cells to flavopiridol diminished cdc2 and cdk2 activity and potently inhibited cell proliferation (IC50=43-83 nM), which was concomitant with the appearance of cells with a sub-G1 DNA content. [2]

 

 

 

参考文献

Rhabdoid Tumor Growth is Inhibited by Flavopiridol Velasco Cimica, Srinivasa Chinni, et al. Clin Cancer Res 2008;14:523-532

Flavopiridol, a Novel Cyclin-dependent Kinase Inhibitor, Suppresses the Growth of Head and Neck Squamous Cell Carcinomas by Inducing Apoptosis Vyomesh Patel,Adrian M. Senderowicz,et al. The Journal of Clinical Investigation November 1998;102:1674-1681

现货,Flavopiridol (Alvocidib) ,美国进口,黄酮类化合物,细胞周期(Cell Cycle / Checkpoint) ,CDK 抑制剂 ,目录号 S1230

价  格: 945

说  明: 详询企业QQ4001681698

货  号:S1230

产  地:美国休斯敦

英 文 名:Flavopiridol (Alvocidib)

供 应 商: 赛导通生物科技

规  格:5mg

品  牌:Selleck

保 质 期:两年

保存条件:零下20摄氏度低温保存

CAS号:146426-40-6

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产品说明书

S1230 Flavopiridol (Alvocidib)

信号转导通路: 细胞周期(Cell Cycle / Checkpoint) >> CDK >> CDK 抑制剂 >> Flavopiridol (Alvocidib)

技术数据:

分子量(MW): 401.84

化学式:

C21H20ClNO5

 

溶解度: DMSO ≥15mg/mL Water <1mg/mL Ethanol ≥8mg/mL

纯度: >99%

稳定性: -20℃ 2 years

CAS号: 146426-40-6

生物活性

 

 

Nanomolar concentrations of flavopiridol inhibited rhabdoid cell growth (IC50-200nmol/L) , induced G1and G2 arrest, and apoptosis in vitro in a concentration-dependent manner. These effects were correlated with the down-modulation of cyclin D1, up-regulation of p21, and induction of caspase 3/7 activities. Flavopiridol (at 7.5 mg/kg) significantly inhibited the growth of xenografted rhabdoid tumors, and its effect was correlated with the induction of p21 and down-modulation of cyclin D1. [1]

Exposure of HNSCC cells to flavopiridol diminished cdc2 and cdk2 activity and potently inhibited cell proliferation (IC50=43-83 nM), which was concomitant with the appearance of cells with a sub-G1 DNA content. [2]

 

 

 

参考文献

Rhabdoid Tumor Growth is Inhibited by Flavopiridol Velasco Cimica, Srinivasa Chinni, et al. Clin Cancer Res 2008;14:523-532

Flavopiridol, a Novel Cyclin-dependent Kinase Inhibitor, Suppresses the Growth of Head and Neck Squamous Cell Carcinomas by Inducing Apoptosis Vyomesh Patel,Adrian M. Senderowicz,et al. The Journal of Clinical Investigation November 1998;102:1674-1681

客户反馈数据

 

(C) In vivo treatment of Tg:Pomc-Pttg;Pomc-eGFP embryos with small-molecule CDK inhibitors (50μM) or 0.2% DMSO as control from 18 to 40 hpf. One hundred to one hundred fifty embryos were treated with each compound. Representative images of live embryos are shown with gross morphology (Right) and pituitary Pomc-GFP–positive cells at higher magnification (Left) at 40 hpf. Embryos exposed to flavopiridol developed early developmental defect before pituitary POMC cell ontogeny occurs. (D) Relative expression of pituitary Pomc-eGFP fluorescence analyzed using Volocity 5.2 software (Improvision; mean ± SE of relative expression, n = 7). (E) R-roscovitine specifically suppresses expansion of pituitary POMC cells overexpressing zPttg from 18 to 48 hpf. Double transgenic Tg:Pomc-Pttg;Prl-RFP embryos were generated by breeding Tg:Pomc-Pttg fish with a previously generated PRL-RFP transgenic line, in which RFP was targeted to pituitary lactotrophs by a zebrafish Prolactin promoter (34). Representative fluorescent microscopy of pituitary POMC-eGFP (a and b) and PRL-RFP (c and d) expression in live Tg:Pomc-Pttg; Pomc-eGFP and Tg:Pomc-Pttg;Prl-RFP embryos treated with 0.2% DMSO (a and c) or 50 μM R-roscovitine (b and d). (F) Relative expression of pituitary POMC-eGFP or PRL-RFP fluorescence were analyzed (mean ± SE of relative expression; n = 10). Results represent one of three similar experiments;*P < 0.02 and **P < 0.000005. (Scale bar, 50 μm.)

 

如果需要长期保存,请于零下二十度低温保存。

禁止用于人体及治疗!

特定的存储和包装每个产品的信息在产品说明书上都有注明 。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20 ° C ,抗体及蛋白等产品建议-60℃。抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。

 

 

 

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