现货,KU-60019 ,CAS号:925701-49-1,美国进口,PI3K / mTOR / AKT , ATM , ATM 抑制剂,selleck,S1570

信号转导通路: PI3K / mTOR / AKT >> ATM >> ATM 抑制剂 >> KU-60019http://www.selleck.cn/ku-60019-S1570.html

技术数据:

分子量(MW): 547.67

化学式:

C30H33N3O5S

 

溶解度: DMSO ≥48mg/mL Water <1mg/mL Ethanol ≥21mg/mL

纯度: >99%

稳定性: at -20℃ 2 years

CAS号: 925701-49-1

生物活性

 

 

KU-60019 is 10-fold more effective than KU-55933 at blocking radiation-induced phosphorylation of key ATM targets in human glioma cells. As expected, KU-60019 is a highly effective radiosensitizer of human glioma cells. A-T fibroblasts were not radiosensitized by KU-60019, strongly suggesting that the ATM kinase is specifically targeted. Furthermore, KU-60019 reduced basal S473 AKT phosphorylation, suggesting that the ATM kinase might regulate a protein phosphatase acting on AKT. In line with this finding, the effect of KU-60019 on AKT phosphorylation was countered by low levels of okadaic acid, a phosphatase inhibitor, and A-T cells were impaired in S473 AKT phosphorylation in response to radiation and insulin and unresponsive to KU-60019. [1]

 

 

 

参考文献

Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling,and inhibits migration and invasion Sarah E. Golding,Elizabeth Rosenberg,et al. Mol Cancer Ther 2009 October;8(10): 2894–2902

 

退换货政策

1、 退换货只针对已付款用户。一张订单Selleck只提供一次退换货服务,为了确保您的权益,请考虑周全后与我们联系。

2、请您确保退换货时,商品、配件、赠品及各种包装完整。

3、因您个人原因造成的商品损坏(如自行使用、分装、受潮、变质、非原物品的等)将不予退换。

4、Selleck目前只支持商品一换一服务,换货时无法加定商品。

5、如您购买商品时Selleck上海办事处已向您提供发票,则办理退货或订单金额发生变更的换货时,请将发票随商品一同返还给Selleck上海办事处赛导通生物科技(上海)有限公司,请您妥善保管发票,如发票丢失,将无法办理退换货。

6、您的订单若办理退换货,运费金额会在您的实际退款中扣除。

 

Write a comment

Comments: 0



赛导通生物科技联系方式:


上海市黄浦区江西中路261号509室,

近南京东路外滩


电话 400-168-1698


传真 021 3326 0586


邮箱: info@selleck.cn 

 技术: tech@selleck.cn



Selleck癌症肿瘤研究周刊


Stu.la 司途拉生物
Stu.la 司途拉生物