现货,KW 2449 ,CAS号:1000669-72-6,美国进口, 血管生成(Angiogenesis), Flt , Flt 抑制剂,selleck,S2158

信号转导通路:  血管生成(Angiogenesis) >> Flt >> Flt 抑制剂 >> 

信号转导通路: 血管生成(Angiogenesis) >> Flt >> Flt 抑制剂 >> KW 2449http://www.selleck.cn/kw-2449-S2158.html

技术数据:

分子量(MW): 332.4

化学式:

C20H20N4O

 

溶解度: DMSO ≥67mg/mL Water <1mg/mL Ethanol ≥67mg/mL

纯度: >99%

稳定性: at -20℃ 2 years

CAS号: 1000669-72-6

生物活性

 

 

KW-2449, a multi-kinase inhibitor of FLT3(IC50 at 6.6pM), ABL(IC50 at 14pM), ABL-T315I and Aurora kinase, is under investigation to treat leukemia patients. KW-2449 potently and selectively inhibits the growth of leukemia cells harboring constitutively activated FLT3 kinase both in vitro and in vivo. In addition, it potently inhibitedABL-T315I, which is associated with IM resistance, with an IC50 value of 4 pM. On the other hand, KW-2449 had little effect on PDGFR, IGF- I R, EGFR, and various serine/threonine kinases even at a concentration of 1 uM. Among various serine/threonine kinases examined, KW-2449 inhibited Aurora A kinase with IC50 of 48 pMp and Aurora B kinase with the equivalent potenc. [1,2]

 

 

 

参考文献

KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation Yukimasa Shiotsu, Hitoshi Kiyoi,et al. Blood 2009;114: 1607-1617

A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response Keith W. Pratz, Jorge Cortes,et al. Blood 2009;113: 3938-3946

退换货政策

1、 退换货只针对已付款用户。一张订单Selleck只提供一次退换货服务,为了确保您的权益,请考虑周全后与我们联系。

2、请您确保退换货时,商品、配件、赠品及各种包装完整。

3、因您个人原因造成的商品损坏(如自行使用、分装、受潮、变质、非原物品的等)将不予退换。

4、Selleck目前只支持商品一换一服务,换货时无法加定商品。

5、如您购买商品时Selleck上海办事处已向您提供发票,则办理退货或订单金额发生变更的换货时,请将发票随商品一同返还给Selleck上海办事处赛导通生物科技(上海)有限公司,请您妥善保管发票,如发票丢失,将无法办理退换货。

6、您的订单若办理退换货,运费金额会在您的实际退款中扣除。


Write a comment

Comments: 0



赛导通生物科技联系方式:


上海市黄浦区江西中路261号509室,

近南京东路外滩


电话 400-168-1698


传真 021 3326 0586


邮箱: info@selleck.cn 

 技术: tech@selleck.cn



Selleck癌症肿瘤研究周刊


Stu.la 司途拉生物
Stu.la 司途拉生物