现货,MLN9708,CAS号:1201902-80-8,美国进口,蛋白酶体(Proteases), Proteasome, Proteasome 抑制剂,selleck,S2181

信号转导通路: 蛋白酶体(Proteases) >> Proteasome >> Proteasome 抑制剂 >> MLN9708http://www.selleck.cn/mln9708-S2181.html

技术数据:

分子量(MW): 517.12

化学式:

C20H23BCl2N2O9

 

溶解度: DMSO ≥103mg/mL Water <1mg/mL Ethanol ≥5mg/mL

纯度: >99%

稳定性: at -20℃ 2 years

CAS号: 1201902-80-8

生物活性

 

 

MLN9708 is an orally bioavailable second generation proteasome inhibitor with potential antineoplastic activity. MLN9708 rapidly hydrolyzes to MLN2238, the biologically active form. It has a shorter proteasome dissociation half-life and improved pharmacokinetics, pharmacodynamics, and antitumor activity compared with bortezomib. It has a larger blood volume distribution at steady state, and analysis of 20S proteasome inhibition and markers of the unfolded protein response confirmed that MLN9708 has greater pharmacodynamic effects in tissues than bortezomib. MLN9708 showed activity in both solid tumor and hematologic preclinical xenograft models, and we found a correlation between greater pharmacodynamic responses and improved antitumor activity. [1][2][3]

 

 

 

参考文献

Evaluation of the Proteasome Inhibitor MLN9708 in Preclinical Models of Human Cancer Edmund C. Lee, Yueying Cao, et al. Cancer Res 2010;70:1970-1980

http://www.cancer.gov/drugdictionary/?CdrID=635527 http://www.cancer.gov/drugdictionary/?CdrID=635527 ;

http://ash.confex.com/ash/2010/webprogram/Paper31616.html http://ash.confex.com/ash/2010/webprogram/Paper31616.html ;

退换货政策

1、 退换货只针对已付款用户。一张订单Selleck只提供一次退换货服务,为了确保您的权益,请考虑周全后与我们联系。

2、请您确保退换货时,商品、配件、赠品及各种包装完整。

3、因您个人原因造成的商品损坏(如自行使用、分装、受潮、变质、非原物品的等)将不予退换。

4、Selleck目前只支持商品一换一服务,换货时无法加定商品。

5、如您购买商品时Selleck上海办事处已向您提供发票,则办理退货或订单金额发生变更的换货时,请将发票随商品一同返还给Selleck上海办事处赛导通生物科技(上海)有限公司,请您妥善保管发票,如发票丢失,将无法办理退换货。

6、您的订单若办理退换货,运费金额会在您的实际退款中扣除。

 

Write a comment

Comments: 0



赛导通生物科技联系方式:


上海市黄浦区江西中路261号509室,

近南京东路外滩


电话 400-168-1698


传真 021 3326 0586


邮箱: info@selleck.cn 

 技术: tech@selleck.cn



Selleck癌症肿瘤研究周刊


Stu.la 司途拉生物
Stu.la 司途拉生物