现货,PD 0332991 HCl ,CAS号:827022-32-2,美国进口,细胞周期(Cell Cycle / Checkpoint) , CDK ,CDK 抑制剂和化合物,S1116,selleck

信号转导通路:  细胞周期(Cell Cycle / Checkpoint) >> CDK >> CDK 抑制剂和化合物 >> 

信号转导通路: 细胞周期(Cell Cycle / Checkpoint) >> CDK >> CDK 抑制剂和化合物 >> PD 0332991 HClhttp://selleck.cn/pd-0332991-S1116.html

技术数据:

分子量(MW): 483.99

化学式:

C24H29N7O2.HCl

 

溶解度: DMSO ≥25mg/mL Water ≥90mg/mL Ethanol ≥4mg/mL

纯度: >99%

稳定性: at -20℃ 2 years

CAS号: 827022-32-2

生物活性

 

 

PD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. This compound is a highly specific inhibitor of cyclindependent kinase 4 (Cdk4) (IC50, 0.011 μmol/L) and Cdk6 (IC50, 0.016 μmol/L), having no activity against a panel of 36 additional protein kinases. [1]

Therapeutic doses of PD 0332991 HCl cause elimination of phospho-Rb and the proliferative marker Ki-67 in tumor tissue and downregulation of genes under the transcriptional control of E2F. [1]

This agent shows significant inhibition in a broad spectrum of human tumor xenografts in vivo. [2]

 

 

 

参考文献

Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts Patricia J. Harvey, Paul R. Keller, et al. Mol Cancer Ther 2004;3:1427-1438

A Novel Therapeutic Combination Using PD 0332991 and Bortezomib: Study in the 5T33MM Myeloma Model Josefina Garcia, Xiangao Huang, et al. Cancer Res 2008;68:5519-5523

 

现货,PD 0332991 HCl ,CAS号:827022-32-2,美国进口,细胞周期(Cell Cycle / Checkpoint) , CDK ,CDK 抑制剂和化合物,S1116,selleck

价  格: 2079

说  明: 详询企业QQ4001681698

货  号:S1116

产  地:美国休斯敦

英 文 名:PD 0332991 HCl

供 应 商: 赛导通生物科技

规  格:5mg

品  牌:selleck

保 质 期:两年

保存条件:零下20摄氏度低温保存

CAS号:827022-32-2

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详细信息分享到

 

信号转导通路: 细胞周期(Cell Cycle / Checkpoint) >> CDK >> CDK 抑制剂和化合物 >> PD 0332991 HClhttp://selleck.cn/pd-0332991-S1116.html

技术数据:

分子量(MW): 483.99

化学式:

C24H29N7O2.HCl

 

溶解度: DMSO ≥25mg/mL Water ≥90mg/mL Ethanol ≥4mg/mL

纯度: >99%

稳定性: at -20℃ 2 years

CAS号: 827022-32-2

生物活性

 

 

PD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. This compound is a highly specific inhibitor of cyclindependent kinase 4 (Cdk4) (IC50, 0.011 μmol/L) and Cdk6 (IC50, 0.016 μmol/L), having no activity against a panel of 36 additional protein kinases. [1]

Therapeutic doses of PD 0332991 HCl cause elimination of phospho-Rb and the proliferative marker Ki-67 in tumor tissue and downregulation of genes under the transcriptional control of E2F. [1]

This agent shows significant inhibition in a broad spectrum of human tumor xenografts in vivo. [2]

 

 

 

参考文献

Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts Patricia J. Harvey, Paul R. Keller, et al. Mol Cancer Ther 2004;3:1427-1438

A Novel Therapeutic Combination Using PD 0332991 and Bortezomib: Study in the 5T33MM Myeloma Model Josefina Garcia, Xiangao Huang, et al. Cancer Res 2008;68:5519-5523

客户反馈数据

 

WM3734 melanoma cells were treated by PD-0332991 for 36 hours; melanoma cells treated by Doxorubicin (DXR) at 0.5 μM is included as a control.

 

 

 

 

 

Serum-deprived T98G glioma cells are restimulated with serum(FBS) with or without 1 Μm PD-0332991.

 

 

 

 

P16INK4A knockdown in INK4A/ARF-wt human glioma cell LN319 potentiates PDGF-Apromoted anchorage-dependent growth in vitro. Soft agar growth of Ink4a/Arf-deficient mAst and LN444 cells treated with PD0332991. (A) IB analysis. (B) Quantification of soft agar assays. β-actin was used as a loading control in all IB experiments. Data are presented as mean ± s.d. and representative of two independent experiments. **, P < 0.01; ***, P < 0.001

(C) In vivo treatment of Tg:Pomc-Pttg;Pomc-eGFP embryos with small-molecule CDK inhibitors (50μM) or 0.2% DMSO as control from 18 to 40 hpf. One hundred to one hundred fifty embryos were treated with each compound. Representative images of live embryos are shown with gross morphology (Right) and pituitary Pomc-GFP–positive cells at higher magnification (Left) at 40 hpf. Embryos exposed to flavopiridol developed early developmental defect before pituitary POMC cell ontogeny occurs. (D) Relative expression of pituitary Pomc-eGFP fluorescence analyzed using Volocity 5.2 software (Improvision; mean ± SE of relative expression, n = 7). (E) R-roscovitine specifically suppresses expansion of pituitary POMC cells overexpressing zPttg from 18 to 48 hpf. Double transgenic Tg:Pomc-Pttg;Prl-RFP embryos were generated by breeding Tg:Pomc-Pttg fish with a previously generated PRL-RFP transgenic line, in which RFP was targeted to pituitary lactotrophs by a zebrafish Prolactin promoter (34). Representative fluorescent microscopy of pituitary POMC-eGFP (a and b) and PRL-RFP (c and d) expression in live Tg:Pomc-Pttg; Pomc-eGFP and Tg:Pomc-Pttg;Prl-RFP embryos treated with 0.2% DMSO (a and c) or 50 μM R-roscovitine (b and d). (F) Relative expression of pituitary POMC-eGFP or PRL-RFP fluorescence were analyzed (mean ± SE of relative expression; n = 10). Results represent one of three similar experiments;*P < 0.02 and **P < 0.000005. (Scale bar, 50 μm.)

如果需要长期保存,请于零下二十度低温保存。

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特定的存储和包装每个产品的信息在产品说明书上都有注明 。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20 ° C ,抗体及蛋白等产品建议-60℃。抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。

 

 

 

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