现货,PD98059,CAS号:167869-21-8,美国进口,MAPK , MEK, MEK 抑制剂和化合物,selleck,目录号S1177

信号转导通路: MAPK >> MEK >> MEK 抑制剂 >> PD98059http://www.selleck.cn/pd-98059-S1177.html

技术数据:

分子量(MW): 267.28

化学式:

C16H13NO3

 

溶解度: DMSO ≥32mg/mL Water <1mg/mL Ethanol ≥3mg/mL

纯度: >99%

稳定性: at -20℃ 2 years

CAS号: 167869-21-8

生物活性

 

 

PD 98059 is a highly selective inhibitor of MEK1 and MEK2 with IC50 values of 4 µM and 50 µM respectively[1–3] . PD98059 does not inhibit activation of other highly related dual-specificity protein kinases or the activity of over 18 other Ser/Thr protein kinases. At concentrations up to 100 µM, PD98059 does not inhibit activation of MKK3 or SEK (MKK4) as determined by measuring phosphorylation at its activation site. [1–3]

 

 

 

参考文献

Regional Selective Neuronal Degeneration after Protein Phosphatase Inhibition in Hippocampal Slice Cultures: Evidence for a MAP Kinase-Dependent Mechanism Elise Runden,Per O. Seglen,et al. The Journal of Neuroscience September 15, 1998;18(18):7296–7305

Mitogen-Activated Protein Kinases (Erk1,2) Phosphorylate Lys-Ser-Pro (KSP) Repeats in Neurofilament Proteins NF-H and NF-M Veeranna,Niranjana D. Amin,et al. The Journal of Neuroscience June 1, 1998;18(11):4008–4021

Nerve Growth Factor Activates Extracellular Signal-Regulated Kinase and p38 Mitogen-Activated Protein Kinase Pathways To Stimulate CREB Serine 133 Phosphorylation JUN XING,JON M. KORNHAUSER,et al. MOLECULAR AND CELLULAR BIOLOGY Apr. 1998;18:1946–1955

 

退换货政策

1、 退换货只针对已付款用户。一张订单Selleck只提供一次退换货服务,为了确保您的权益,请考虑周全后与我们联系。

2、请您确保退换货时,商品、配件、赠品及各种包装完整。

3、因您个人原因造成的商品损坏(如自行使用、分装、受潮、变质、非原物品的等)将不予退换。

4、Selleck目前只支持商品一换一服务,换货时无法加定商品。

5、如您购买商品时Selleck上海办事处已向您提供发票,则办理退货或订单金额发生变更的换货时,请将发票随商品一同返还给Selleck上海办事处赛导通生物科技(上海)有限公司,请您妥善保管发票,如发票丢失,将无法办理退换货。

6、您的订单若办理退换货,运费金额会在您的实际退款中扣除。

 

Write a comment

Comments: 0



赛导通生物科技联系方式:


上海市黄浦区江西中路261号509室,

近南京东路外滩


电话 400-168-1698


传真 021 3326 0586


邮箱: info@selleck.cn 

 技术: tech@selleck.cn



Selleck癌症肿瘤研究周刊


Stu.la 司途拉生物
Stu.la 司途拉生物