现货,PI-103 ,CAS号: 371935-74-9 ,美国进口, PI3K / mTOR / AKT,DNA-PK,DNA-PK 抑制剂 ,PI-103 ,selleck,S1038

信号转导通路: PI3K / mTOR / AKT >> DNA-PK >> DNA-PK 抑制剂 >> PI-103http://selleck.cn/pi-103-S1038.html

技术数据:

分子量(MW): 348.36

化学式:

C19H16N4O3

溶解度: DMSO ≥24mg/mL Water <1mg/mL Ethanol <1mg/mL

纯度: >99%

稳定性: at -20℃ 2 years

CAS号: 371935-74-9

生物活性

 

PI-103 is a potent, cell-permeable, ATP-competitive PI3K family members inhibitor with IC50 of 2, 8, 20, 26, 48, 83, 88, 150 nM for DNA-PK, p110α, mTORC1, PI3-KC2β, p110δ, mTORC2, p110β, and p110γ, respectively. It shows little activity against a wide array of protein kinases at 10 mM. It blocks glioma proliferation by blocking the PI 3-K/Akt pathway in vitro and in vivo. PI-103 was essentially cytostatic for cell lines and induced cell cycle arrest in the G1 phase. In blast cells, PI-103 inhibited leukemic proliferation, the clonogenicity of leukemic progenitors and induced mitochondrial apoptosis, especially in the compartment containing leukemic stem cells. PI-103 had additive proapoptotic effects with etoposide in blast cells and in immature leukemic cells. [1][2][3]

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