现货,Pomalidomide, CAS号:19171-19-8,美国进口,细胞凋亡(Apoptosis) , TNF-alpha, TNF-alpha 抑制剂和化合物,S1567,selleck

信号转导通路: 细胞凋亡(Apoptosis) >> TNF-alpha >> TNF-alpha 抑制剂和化合物 >> Pomalidomidehttp://www.dxy.cn/redirect?url=http://selleck.cn/pomalidomide-cc-4047-S1567.html

技术数据:

分子量(MW): 273.24

化学式:

C13H11N3O4

 

溶解度: DMSO ≥55mg/mL Water <1mg/mL Ethanol <1mg/mL

纯度: >99%

稳定性: at -20℃ 2 years

CAS号: 19171-19-8

生物活性

 

 

Pomalidomide is tumor necrosis factor-α inhibitor and a new immunomodulator with an IC50 of 1 μM. It is a derivative of thalidomide and is 10,000 times more potent than thalidomide in terms of inhibition of tumor necrosis factor-α. Additionally, it helps to restrict tumors’ necessary blood vessel growth. Compared to thalidomide, pomalidomide has demonstrated enhanced immunological effects in lab testing, including an approximately 500-2,000 times greater potency at stimulating the proliferation of T-cells. Like thalidomide, pomalidomide appears to function through multiple pathways to inhibit myeloma cells’ growth and survival. [1][2]

 

 

 

参考文献

http://en.wikipedia.org/wiki/Pomalidomide http://en.wikipedia.org/wiki/Pomalidomide ;

Mechanism of action of immunomodulatory drugs (IMiDS) in multiple myeloma. Quach H et al. Leukemia. 2010 Jan;;24(1):22-32.

退换货政策

1、 退换货只针对已付款用户。一张订单Selleck只提供一次退换货服务,为了确保您的权益,请考虑周全后与我们联系。

2、请您确保退换货时,商品、配件、赠品及各种包装完整。

3、因您个人原因造成的商品损坏(如自行使用、分装、受潮、变质、非原物品的等)将不予退换。

4、Selleck目前只支持商品一换一服务,换货时无法加定商品。

5、如您购买商品时Selleck上海办事处已向您提供发票,则办理退货或订单金额发生变更的换货时,请将发票随商品一同返还给Selleck上海办事处赛导通生物科技术(上海)有限公司,请您妥善保管发票,如发票丢失,将无法办理退换货。

6、您的订单若办理退换货,运费金额会在您的实际退款中扣除。

 

Write a comment

Comments: 0



赛导通生物科技联系方式:


上海市黄浦区江西中路261号509室,

近南京东路外滩


电话 400-168-1698


传真 021 3326 0586


邮箱: info@selleck.cn 

 技术: tech@selleck.cn



Selleck癌症肿瘤研究周刊


Stu.la 司途拉生物
Stu.la 司途拉生物