现货,SB939,CAS号:929016-96-6,美国进口, HDAC-HSP-Aurora , HDAC ,HDAC 抑制剂和化合物,selleck,S1515

信号转导通路: HDAC-HSP-Aurora >> HDAC >> HDAC 抑制剂和化合物 >> SB939http://www.dxy.cn/redirect?url=http://selleck.cn/sb939-S1515.html

技术数据:

分子量(MW): 358.48

化学式:

C20H30N4O2

 

溶解度: DMSO ≥72mg/mL Water <1mg/mL Ethanol ≥72mg/mL

纯度: >99%

稳定性: at -20℃ 2 years

CAS号: 929016-96-6

生物活性

 

 

SB939 is a novel potent and orally active histone deacetylase inhibitor with an IC50 of 52 nM for HDAC1 and a GI50 of 0.56 µM for Colo205. Its IC50 for HCT-116 colon cancer cell line and HL-60 acute myeloid leukemia cell line is 0.48 μM and 70 nM, respectively. In vitro, SB939 inhibits class I, II, and IV HDACs, with no effects on other zinc binding enzymes, and shows significant antiproliferative activity against a wide variety of tumor cell lines. It has very favorable pharmacokinetic properties after oral dosing in mice, with >4-fold increased bioavailability and 3.3-fold increased half-life over suberoylanilide hydroxamic acid (SAHA). In contrast to SAHA, SB939 accumulates in tumor tissue and induces a sustained inhibition of histone acetylation in tumor tissue. [1][2][3]

 

 

 

参考文献

SB939, a Novel Potent and Orally Active Histone Deacetylase Inhibitor with High Tumor Exposure and Efficacy in Mouse Models of Colorectal Cancer Kanda Sangthongpitag, Chang Yong Hu, et al. Mol Cancer Ther 2010;9:642-652

http://www.cancer.gov/drugdictionary/?CdrID=559644 http://www.cancer.gov/drugdictionary/?CdrID=559644 ;

New patented histone deacetylase inhibitors. Novotny-Diermayr V et al. Mol Cancer Ther. 2010 Mar;9(3):642-52.

退换货政策

1、 退换货只针对已付款用户。一张订单Selleck只提供一次退换货服务,为了确保您的权益,请考虑周全后与我们联系。

2、请您确保退换货时,商品、配件、赠品及各种包装完整。

3、因您个人原因造成的商品损坏(如自行使用、分装、受潮、变质、非原物品的等)将不予退换。

4、Selleck目前只支持商品一换一服务,换货时无法加定商品。

5、如您购买商品时Selleck上海办事处已向您提供发票,则办理退货或订单金额发生变更的换货时,请将发票随商品一同返还给Selleck上海办事处赛导通生物科技术(上海)有限公司,请您妥善保管发票,如发票丢失,将无法办理退换货。

6、您的订单若办理退换货,运费金额会在您的实际退款中扣除。

 

Write a comment

Comments: 0



赛导通生物科技联系方式:


上海市黄浦区江西中路261号509室,

近南京东路外滩


电话 400-168-1698


传真 021 3326 0586


邮箱: info@selleck.cn 

 技术: tech@selleck.cn



Selleck癌症肿瘤研究周刊


Stu.la 司途拉生物
Stu.la 司途拉生物