现货,TW-37 ,CAS号:877877-35-5,美国进口,细胞凋亡(Apoptosis) ,Bcl-2, Bcl-2 抑制剂 ,目录号S1121

信号转导通路: 细胞凋亡(Apoptosis) >> Bcl-2 >> Bcl-2 抑制剂 >> TW-37http://www.dxy.cn/redirect?url=http://www.selleck.cn/tw-37-S1121.html

技术数据:

分子量(MW): 573.7

化学式:

C33H35NO6S

 

溶解度: DMSO ≥115mg/mL Water <1mg/mL Ethanol ≥4mg/mL

纯度: >99%

稳定性: at -20℃ 2 years

CAS号: 877877-35-5

生物活性

 

 

TW-37 is a Bcl-2 protein family inhibitor with a Ki of 0.29 μM. TW-37 binds to the BH3 binding groove in Bcl-2 protein competing with BH3 peptides derived from Bid, Bim, and Bad proteins. TW-37 binds to Bcl-2 with a Ki value of 290 nM and also to Bcl-xL and Mcl-1 with high affinities. TW-37 potently inhibits cell growth in PC-3 prostate cancer cells with an IC50 value of 200 nM and effectively induces apoptosis in a dose-dependent manner. TW-37 has an IC50 of 1.1 μM for primary human endothelial cells and averaged 0.3 μM for head and neck cancer cells (OSCC3, UM-SCC-1, and UMSCC-74A). The combination of TW-37 and cisplatin showed enhanced cytotoxic effects for endothelial cells and HNSCC in vitro, compared with single agent treatment. [1][2]

 

 

 

参考文献

Antiangiogenic Effect of TW37, a Small-Molecule Inhibitor of Bcl-2 Esther Joo, Zhihong Dong, et al. Cancer Res 2006;66:8698-8706

TW-37, a small-molecule inhibitor of Bcl-2, mediates S-phase cell cycle arrest and suppresses head and neck tumor angiogenesis Benjamin D. Zeitlin, Zhaocheng Zhang, et al. Mol Cancer Ther 2009;8:893-903

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