现货,Vorinostat (SAHA),CAS号:149647-78-9,美国进口,HDAC-HSP-Aurora ,HDAC , HDAC 抑制剂和化合物,S1047,selleck

信号转导通路: HDAC-HSP-Aurora >> HDAC >> HDAC 抑制剂 >> Vorinostat (SAHA)http://selleck.cn/vorinostat-saha-S1047.html

技术数据:

分子量(MW): 264.3

化学式:

C14H20N2O3

 

溶解度: DMSO ≥53mg/mL Water <1mg/mL Ethanol ≥5mg/mL

纯度: >99%

稳定性: at -20℃ 2 years

CAS号: 149647-78-9

生物活性

 

 

Suberoylanilide hydroxamic acid (SAHA). Tumor suppressor genes are often silenced in human cancer; this can occur by transcriptional repression by deacetylation in the promoter regions, mediated by histone deacetylase (HDAC). HDAC inhibitors can block cancer cell growth by restoring expression of tumor suppressor genes. Vorinostat efficiently suppressed MES-SA cell growth at a low dosage (3 μM) already after 24 hours treatment. Decrease of cell survival was even more pronounced after prolonged treatment and reached 9% and 2% after 48 and 72 hours of treatment, respectively. Colony forming capability of MES-SA cells treated with 3 μM vorinostat for 24 and 48 hours was significantly diminished and blocked after 72 hours. [2]

 

 

 

参考文献

Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells Takashi Kumagai,Naoki Wakimoto,et al. Int. J. Cancer 2007;121:656–665

Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo Andelko Hrzenjak,Farid Moinfar,et al. Molecular Cance 2010;9:49

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