美国赛力克生命科学HDAC信号通路,HSP信号通路,Aurora信号通路新品发布

 

靶点

HDAC (29)

Aurora Kinase (23)

HSP90 (19)

Kinesin Spindle Protein (4)

Sirtuin (3)

 

HDAC-HSP-Aurora

Aurora kinases which play a key role in cell prefabrication are serine/threonine kinases. The Aurora protein kinases family, including Aurora A, Aurora B and Aurora C, are associated to the stability of chromosome. Heat shock proteins (HSP) are a class of functionally related proteins involved in the folding and unfolding of other proteins. As molecular chaperones, Hsps bind nonnative states of other proteins and aid them to reach a functional conformation, through the expenditure of ATP. HDACs, also called Histone deacetylase appear to be core enzymes in the regulation of gene expression by binding to the negatively charged phosphate groups on the DNA backbone with its positively charged histone tails.

最新产品

PCI-34051

MPC-3100 MPC-3100是人工合成的有效的Hsp90小分子抑制剂,IC50为60 nM。

HDAC4 Antibody WB

AT13387 AT13387 是Hsp90 选择性小分子抑制剂,作用于A375, MV4-11, NCI-H1975和SKBr3细胞系时 IC50 分别为18, 12, 22和 55 nM。

Ganetespib (STA-9090) Ganetespib (STA-9090) is a unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM for OSA 8 cells.

 

 

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