现货,BI6727 (Volasertib),CAS号:755038-65-4,美国进口,细胞周期(Cell Cycle / Checkpoint), PLK , PLK 抑制剂,selleck,S2235

信号转导通路: 细胞周期(Cell Cycle / Checkpoint) >> PLK >> PLK 抑制剂 >> BI6727 (Volasertib)http://www.selleck.cn/bi6727-volasertib-S2235.html

技术数据:

分子量(MW): 618.81

化学式:

C34H50N8O3

 

溶解度: DMSO ≥23mg/mL Water <1mg/mL Ethanol ≥124mg/mL

纯度: >99%

稳定性: at -20℃ 2 years

CAS号: 755038-65-4

生物活性

 

 

BI 6727 is a highly potent Polo-like kinase inhibitor with an IC50 of 0 .87 nM BI 6727 has an EC50 of 11-37 nM on a panel of cancer cell lines and selective dihydropteridinone with distinct properties. BI 6727 has a pharmacokinetic profile favoring sustained exposure of tumor tissues with a high volume of distribution and a long terminal half-life in mice. BI 6727 has physicochemical and pharmacokinetic properties that allow in vivo testing of i.v. as well as oral formulations, adding flexibility to dosing schedules. BI 6727 shows marked antitumor activity in multiple cancer models, including a model of taxane-resistant colorectal cancer. [1][2][3]

 

 

 

参考文献

BI 6727, A Polo-like Kinase Inhibitor with Improved Pharmacokinetic Profile and Broad Antitumor Activity Martin Steegmaier, Matthias Hoffmann, et al. Clin Cancer Res 2009;15:3094-3102

Polo-Like Kinase (PLK) Inhibitors in Preclinical and Early Clinical Development in Oncology PATRICK SCHÖFFSKI The Oncologist 2009;14:559–570

Small Molecule Kinase Inhibitor Screen Identifies Polo-Like Kinase 1 as a Target for Neuroblastoma Tumor-Initiating Cells Alessandro Datti, Mayumi Fujitani, et al. Cancer Res 2011;71:1385-1395

退换货政策

1、 退换货只针对已付款用户。一张订单Selleck只提供一次退换货服务,为了确保您的权益,请考虑周全后与我们联系。

2、请您确保退换货时,商品、配件、赠品及各种包装完整。

3、因您个人原因造成的商品损坏(如自行使用、分装、受潮、变质、非原物品的等)将不予退换。

4、Selleck目前只支持商品一换一服务,换货时无法加定商品。

5、如您购买商品时Selleck上海办事处已向您提供发票,则办理退货或订单金额发生变更的换货时,请将发票随商品一同返还给Selleck上海办事处赛导通生物科技(上海)有限公司,请您妥善保管发票,如发票丢失,将无法办理退换货。

6、您的订单若办理退换货,运费金额会在您的实际退款中扣除。

 

Write a comment

Comments: 0



赛导通生物科技联系方式:


上海市黄浦区江西中路261号509室,

近南京东路外滩


电话 400-168-1698


传真 021 3326 0586


邮箱: info@selleck.cn 

 技术: tech@selleck.cn



Selleck癌症肿瘤研究周刊


Stu.la 司途拉生物
Stu.la 司途拉生物