现货,SB 202190 ,CAS号:152121-30-7,美国进口,MAPK , p38 MAPK , p38 MAPK 抑制剂和化合物,,selleck,S1077

信号转导通路: MAPK >> p38 MAPK >> p38 MAPK 抑制剂和化合物 >> SB 202190http://selleck.cn/sb-202190-S1077.html

技术数据:

分子量(MW): 331.34

化学式:

C20H14N3OF

 

溶解度: DMSO ≥66mg/mL Water <1mg/mL Ethanol ≥32mg/mL

纯度: >99%

稳定性: at -20℃ 2 years

CAS号: 152121-30-7

生物活性

 

 

SB202190 enhanced the growth of THP-1 and MV4-11 cells. In the presence of SB202190, the ED50 values for the farnesyltransferase inhibitor FPT inhibitor II and MEK inhibitor U0126 were significantly decreased.SB202190 increased the phosphorylation of C-Raf and extracellular regulated kinase (ERK). [1]

SB202190 suppressed the kinase activity of p38, leading to inhibition of activation of MAPKAPK2 and then the subsequent phosphorylation of hsp27 in LPS-treated macrophages both in vitro and in vivo. [2]

SB202190 blocked p38 half maximally at 30 nM. Concentrations as high as 30,000 nM did not inhibit ERK and JNK activity. [3]

 

 

 

参考文献

Activation of the ras genes in malignant and premalignant colorectal tumors. Glarakis IS, et al. Oncol Rep. 1998 Nov-Dec;5(6):1451-4.

Transformation of mammalian cells by constitutively active MAP kinase kinase Mansour SJ,et al. Science 1994;265(5174):966-970

p38 MAP kinase inhibition promotes primary tumour growth via VEGF independent mechanism. O'Sullivan AW,et al. World J Surg Oncol. 2009 Nov 15;7:89.

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